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Inventi Impact: NDDS

Articles

  • Inventi:pndds/30018/19
    Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation
    Research 2019 : October - December
    Jeand Baloch, Muhammad Farhan Sohail, Hafiz Shaib Sarwar, Maria Hassan Kiani, Gul Majid Khan, Sarwat Jahan, Muhammad Rafay, Muhammad Tausif Chaudhry, Masoom Yasinzai, Gul Shahnaz

    Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems\n(SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and o_er many\nvaluable opportunities in drug delivery. Chlorpromazine, an antipsychotic agent with poor aqueous\nsolubility--with extensive first-pass metabolism-can be a suitable candidate for the development of\nSNEDDS. The current study was designed to develop triglyceride-based SNEDDS of chlorpromazine\nto achieve improved solubility, stability, and oral bioavailability. Materials and Methods: Fifteen\nSNEDDS formulations of each short, medium, and long chain, triglycerides were synthesized and\ncharacterized to achieve optimized formulation. The optimized formulation was characterized for\nseveral in vitro and in vivo parameters. Results: Particle size, zeta potential, and drug loading of\nthe optimized SNEDDS (LCT14) were found to be������

    How to Cite this Article
    Attribution/ CC Compliant Citation: Baloch, Jeand, et al. \"Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation.\" Medicina 55.5 (2019):210; https://doi:10.3390/medicina55050210; http://creativecommons.org/licenses/by/4.0/;Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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